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JAMA: Advisory Committee on Immunization Practices at a Crossroads
EXCERPT Vaccines are one of the greatest global public health achievements. Vaccine recommendations have been critical to the global eradication of smallpox and the elimination of polio, measles, rubella, and congenital rubella syndrome in the US. They have also dramatically decreased cases of hepatitis, meningitis, mumps, pertussis (whooping cough), pneumonia, tetanus, and varicella (chickenpox), and prevented cancers caused by hepatitis B virus and human papillomaviruses.1 Recent scientific advancements e...
Jun 16, 2025
BMC Neurology: Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients
ABSTRACT Background Neuropsychiatric symptoms emerged early in the COVID-19 pandemic as a key feature of the virus, with research confirming a range of neuropsychiatric manifestations linked to acute SARS-CoV-2 infection. However, the persistence of neurological symptoms in the post-acute and chronic phases remains unclear. This meta-analysis assesses the long-term neurological effects of COVID-19 in recovered patients, providing insights for mental health service planning. Methods A comprehensive litera...
Jun 14, 2025
BMJ Open Respiratory Research: Bidirectional relationship between sleep problems and long COVID: a longitudinal analysis of data from the COVIDENCE UK study
ABSTRACT Background Studies into the bidirectional relationship between sleep and long COVID have been limited by retrospective pre-infection sleep data and infrequent post-infection follow-up. We therefore used prospectively collected monthly data to evaluate how pre-infection sleep characteristics affect risk of long COVID and to track changes in sleep duration during the year after SARS-CoV-2 infection. Methods COVIDENCE UK is a prospective, population-based UK study of COVID-19 in adults. We includ...
Jun 14, 2025
Nature Biomedical Engineering: Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection
ABSTRACT Bioluminescence holds notable promise as a modality in diagnostics due to its high signal-to-noise ratio and absence of incident radiation. However, challenges arise from rapid signal decay and reduced enzyme activity when linked to targeting molecules, limiting its reliability in point-of-care diagnostic applications. Here we introduce the luminescence cascade-based sensor (LUCAS) assay, an enzyme cascade system capable of detecting analytes with ultrahigh sensitivity and prolonged bioluminescence...
May 30, 2025
Nature Immunology: Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
ABSTRACT Mucosal delivery of vaccine boosters induces robust local protective immune responses even without any adjuvants. Yet, the mechanisms by which antigen alone induces mucosal immunity in the respiratory tract remain unclear. Here we show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with 1 μg of mRNA–LNP vaccine encoding the full-length SARS-CoV-2 spike protein (Pfizer/BioNTech BNT162b2), elicits protective mucosal immunity by r...
May 13, 2025